Current Research

Our current research includes studies in pre-exposure prophylaxis, long-acting injectable antiretroviral therapy, linkage to HIV care and treatment, COVID-19 testing and vaccination, anal cancer prevention and substance use disorder treatment.

Studies within this section denote current recruitment and enrollment.

Interested in participating in a research study? Follow the QR code here.

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The BIG Chicago study explores how providing guaranteed basic income can affect the lives of young people in Chicago living with HIV, aged 18 to 35. Everyone who joins the study helps us learn by completing paid surveys about their experiences. By joining, participants can help us understand how financial support might improve health and well-being for people living with HIV—and inform future programs and research in this area.

Study spotlight: BIG Chicago

Study spotlight: Conectados Study

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Eligibility: Identify as a Latino/e LGBTQ+ man, ages 16-29 year old.

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  • The goal of this project is to test a social network intervention aimed at improving (or maintaining) engagement in HIV care among adolescent and younger adult Black MSM and transgender patients. The social network intervention includes recruitment of individuals from the social network that serve a supportive function and motivate these individuals to drive adherence to HIV primary care: retention to clinic appointments and adherence to antiretrovirals. This study is a randomized trial funded by the National Institutes of Health. For more information contact Alida Bouris at abouris@uchicago.edu

  • Eligibility: Identify as Black/African American, over 18 year old, all genders.

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  • Lead Investigator:

    • Alida Bouris, PhD, MSW

    Case Management Dyad, CM2, is a study funded by the National Institute of Mental Health that provides people vulnerable to and living with HIV support to address their financial well-being goals. Using a Hybrid Type II randomized controlled trial design, CM2 evaluates both the effectiveness of a dyadic case management model on financial well-being and HIV care and prevention outcomes as well as the implementation strategies needed to support case managers and sustain the intervention.

  • Lead Investigator:

    • Anna Hotton PhD, MPH

  • Lead Investigator:

    • Anna Hotton PhD, MPH

  • Lead Investigator:

    • Darnell Motley, PhD

  • Lead Investigator:

    • Jade Pagkas-Bather, MD, MPH

  • Lead Investigator:

    • Jade Pagkas-Bather, MD, MPH

  • Lead Investigators:

    • Jade Pagkas-Bather, MD, MPH

    • Darnell Motley, PhD

    The BIG Chicago study explores how providing guaranteed basic income can affect the lives of young people in Chicago living with HIV, aged 18 to 35. Everyone who joins the study helps us learn by completing paid surveys about their experiences. By joining, participants can help us understand how financial support might improve health and well-being for people living with HIV—and inform future programs and research in this area.

  • Lead Investigators:

    • John Schneider, MD, MPH (University of Chicago)

    • Duncan Dustin, ScD, ScM (Columbia University)

    • Justin Knox, PhD, MPH, MSc (Columbia University)

    Sponsor: Columbia University

    “PrEP Uptake and Adherence Among Young Black MSM: Neighborhood and Network Determinants” (N2) is a behavioral study. This study aims to determine the relationship between neighborhood-level factors and pre-exposure prophylaxis (PrEP) uptake and adherence; characterize the relationship between social and sexual network characteristics and PrEP uptake and adherence; and identify interactive effects of neighborhoods and social and sexual networks on PrEP uptake and adherence.

    The N2 Cannabis PrEP Study uses innovative methods to rigorously investigate relationships between cannabis use (including polysubstance use), HIV prevention behaviors (e.g., PrEP use/adherence) and biological vulnerability to HIV infection among an existing cohort of Black men who have sex with men (MSM).

    The N2 Stimulant Study characterizes stimulant use in the N2 cohort, including use of other drugs (i.e. polysubstance use), and patterns of use over time (e.g., incidence, persistence); identifies network-level and neighborhood-level determinants of stimulant use; and determines how stimulant use impacts HIV transmission through prevention (e.g. PrEP adherence, condom use), treatment (e.g. ART adherence) and amplified biological vulnerability (i.e. rectal inflammation).

  • Lead Investigator:

    • Mai Pho, MD, MPH

  • Lead Investigator:

    • Jessica Ridgway, MD, MPH

  • Lead Investigator:

    • Jessica Ridgway, MD, MPH

  • Lead Investigator:

    • John Schneider, MD, MPH

  • Lead Investigator:

    • John Schneider, MD, MPH

  • Lead Investigator:

    • Kim Stanford, MD

  • Lead Investigators:

    • Samuel Bunting, MD, MSHA

    • Anu Hazra, MD

    The purpose of this research is to perform a pilot test to understand preliminary efficacy of a PrEP navigation intervention for PLWMI who are receiving psychiatric care on an IPU. 

  • Lead Investigators:

    • John Schneider, MD, MPH

    • Sarah Keedy, PhD

    This study aims to identify addressable mechanisms with the potential to improve HIV prevention. This study will explore mechanisms, specifically neurocognitive impacts of heavy cannabis use.